Cytotoxic and Genotoxic Effects of Aqueous Extracts of Rosmarinus officinalis L., Lavandula stoechas L. and Tilia cordata Mill. on in vitro Human Peripheral Blood Lymphocytes
| Autor: | Tülay Aşkin Çelik, Özlem Sultan Aslantürk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Tilia cordata
tilia cordata Rosmarinus lavandula stoechas rosmarinus officinalis insan periferal kan lenfositleri lcsh:Science lcsh:Science (General) genotoksik etki genotoxic effect biology Traditional medicine Chemistry General Medicine biology.organism_classification Peripheral blood In vitro lcsh:TA1-2040 Officinalis human peripheral lymphocytes cytotoxic effect lcsh:Q lcsh:Engineering (General). Civil engineering (General) Lavandula stoechas sitotoksik etki lcsh:Q1-390 |
| Zdroj: | Cumhuriyet Science Journal, Vol 39, Iss 1, Pp 127-143 (2018) |
| ISSN: | 2587-2680 |
| Popis: | The aim of this study was to investigation of in vitro cytotoxic and genotoxic effects of infusion and decoction aqueous extracts obtained from Rosmarinus officinalis, Lavandula stoechas L. and Tilia cordata Mill. on human peripheral blood lymphocytes. For this purpose, lymphocytes taken from 3 females, were treated with aqueous extracts of R. officinalis (1.5 and 3 mg/ml), L. stoechas (0,4 and 1,2 mg/ml) and T. cordata (1 mg/ml and 3 mg/ml) for 48 hours. PBS was used as negative control and Mitomycin C (MMC) (0,25 μg/ml) was used as positive control in experiments. Cytotoxic effect of extracts on lymphocytes was determined by calculating mitotic index. Also, chromosome aberrations micronucleus formations were determined. All extracts considerably decreased the cell division in lymphocytes depending on the increased concentration in comparison with control groups (p |
| Databáze: | OpenAIRE |
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