Monoclonality and oligoclonality of T cell receptor gene in angioimmunoblastic T cell lymphoma
| Autor: | Zahid H Shah, Susan Harris, John L. Smith, Elizabeth Hodges |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Angioimmunoblastic T-cell lymphoma Gene Rearrangement gamma-Chain T-Cell Antigen Receptor Receptors Antigen T-Cell alpha-beta T cell T-cell receptor DNA Neoplasm General Medicine Gene rearrangement Biology Lymphoma T-Cell medicine.disease Polymerase Chain Reaction Pathology and Forensic Medicine Lymphoma medicine.anatomical_structure Immunoblastic Lymphadenopathy Molecular genetics Monoclonal Neoplastic Stem Cells medicine Cancer research Humans T-cell lymphoma Gene Rearrangement beta-Chain T-Cell Antigen Receptor |
| Zdroj: | Journal of Clinical Pathology. 62:177-181 |
| ISSN: | 0021-9746 |
| DOI: | 10.1136/jcp.2007.054239 |
| Popis: | Angioimmunoblastic T cell lymphoma (AILT) is an aggressive T cell lymphoma with an incidence of approximately 1-2% of all non-Hodgkin lymphoma. The detection of clonal T cell receptor (TCR) gene rearrangements helps in the diagnosis of T cell malignancies such as AILT, where morphological and immunohistological investigations are not always sufficient to reach a definitive diagnosis. TCR beta (TCRB) and TCR gamma (TCRG) gene rearrangements were analysed from 17 WHO-defined cases of AILT by PCR for the presence of TCR clonality. TCRB gene rearrangements were sequenced to identify molecular signature(s) common among this patient group. Monoclonal and oligoclonal TCRB and TCRG gene rearrangements were detected in all cases. BV17S1 was slightly over-represented compared to the use of other Vbeta gene segments; however, no preferential usage of J gene segment(s) was detected. The results of this study emphasise that TCR clonality and oligoclonality is a diagnostic feature of AILT and that BV17S1 is over-represented with no other common molecular findings. |
| Databáze: | OpenAIRE |
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