Efficacy of a Therapeutic Diet on Dogs With Signs of Cognitive Dysfunction Syndrome (CDS): A Prospective Double Blinded Placebo Controlled Clinical Study
| Autor: | Isabelle Mougeot, Gary M. Landsberg, Norton W. Milgram, Xu Hui, Yuanlong Pan, Sandeep Bhatnagar, Stephanie Kelly, Cari Gardner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences B vitamins Endocrinology Diabetes and Metabolism arginine lcsh:TX341-641 Disease Placebo 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Dementia Medium-chain triglyceride Cognitive decline Omega 3 fatty acid Nutrition Original Research Nutrition and Dietetics business.industry 04 agricultural and veterinary sciences medicine.disease BPB omega-3 PUFAs antioxidants cognitive dysfunction syndrome chemistry Docosahexaenoic acid medium-chain triglycerides dog business lcsh:Nutrition. Foods and food supply 030217 neurology & neurosurgery Food Science |
| Zdroj: | Frontiers in Nutrition, Vol 5 (2018) Frontiers in Nutrition |
| ISSN: | 2296-861X |
| DOI: | 10.3389/fnut.2018.00127 |
| Popis: | Cognitive dysfunction syndrome (CDS) is a common condition in senior dogs, which may be analogous to dementia such as Alzheimer's disease (AD) in people. In humans, AD has been associated with many risk factors such as reduced cerebral glucose metabolism, docosahexaenoic acid (DHA) deficiency, chronic oxidative stress, and chronic inflammation. By targeting some of these risk factors, we have developed two nutritional solutions (medium chain triglyceride, MCT and Brain Protection Blend, BPB) to enhance cognitive function and slow aging-induced cognitive decline. These have been positively evaluated in colony housed senior dogs and cats. The objective of this clinical study was to evaluate the effects of diets with MCTs and the BPB on client-owned dogs with CDS. Participating veterinary clinics screened senior dogs for signs of CDS as determined by a Senior Canine Behavior Questionnaire and a Canine Medical Health Questionnaire. Eighty-seven dogs were randomly enrolled into one of three diet groups with 29 dogs per group: Control, 6.5% MCT oil + BPB (6.5% MCT diet), 9% MCT oil + BPB (9% MCT diet). Diets were fed for a period of 90 days, and each dog's CDS signs were re-evaluated at day 30 and day 90. All 6 categories of the CDS signs were significantly improved (p |
| Databáze: | OpenAIRE |
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