Enzymatic Synthesis of Fatty Hydroxamic Acid Derivatives Based on Palm Kernel Oil
| Autor: | Hossein Jahangirian, Yadollah Gharayebi, Jelas Haron, Mazyar Peyda, Nor Azah Yusof, Roshanak Rafiee-Moghaddam, Anuar Kassim, Sidik Silong |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Proton Magnetic Resonance Spectroscopy
Pharmaceutical Science Palm Oil methyl fatty hydroxamic acids Hydroxamic Acids palm kernel oil Article lipozyme Analytical Chemistry Catalysis lcsh:QD241-441 chemistry.chemical_compound Hydroxylamine lcsh:Organic chemistry Spectroscopy Fourier Transform Infrared Drug Discovery Plant Oils Organic chemistry Physical and Theoretical Chemistry Chemical composition isopropyl fatty hydroxamic acids enzymatic reaction Hydroxamic acid Fatty Acids Organic Chemistry food and beverages Lipase Enzymatic synthesis Elements Hexane chemistry benzyl fatty hydroxamic acids Chemistry (miscellaneous) Hydroxylamine derivatives Molecular Medicine Palm kernel oil |
| Zdroj: | Molecules, Vol 16, Iss 8, Pp 6634-6644 (2011) Molecules; Volume 16; Issue 8; Pages: 6634-6644 Molecules |
| ISSN: | 1420-3049 |
| Popis: | Fatty hydroxamic acid derivatives were synthesized using Lipozyme TL IM catalyst at biphasic medium as the palm kernel oil was dissolved in hexane and hydroxylamine derivatives were dissolved in water: (1) N-methyl fatty hydroxamic acids (MFHAs); (2) N-isopropyl fatty hydroxamic acids (IPFHAs) and (3) N-benzyl fatty hydroxamic acids (BFHAs) were synthesized by reaction of palm kernel oil and N-methyl hydroxylamine (N-MHA), N-isopropyl hydroxylamine (N-IPHA) and N-benzyl hydroxylamine (N-BHA), respectively. Finally, after separation the products were characterized by color testing, elemental analysis, FT-IR and 1H-NMR spectroscopy. For achieving the highest conversion percentage of product the optimum molar ratio of reactants was obtained by changing the ratio of reactants while other reaction parameters were kept constant. For synthesis of MFHAs the optimum mol ratio of N-MHA/palm kernel oil = 6/1 and the highest conversion was 77.8%, for synthesis of IPFHAs the optimum mol ratio of N-IPHA/palm kernel oil = 7/1 and the highest conversion was 65.4% and for synthesis of BFHAs the optimum mol ratio of N-BHA/palm kernel oil = 7/1 and the highest conversion was 61.7%. |
| Databáze: | OpenAIRE |
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