Effect of short-term outlet obstruction on rat bladder nerve density and contractility
| Autor: | R. M. Levin, M. M. Barendrecht, P. Chichester, M. C. Michel |
|---|---|
| Přispěvatelé: | Urology, Other Research, Pharmacology and pharmacotherapeutics |
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Contraction (grammar) Neurofilament Carbachol Urinary Bladder In Vitro Techniques Potassium Chloride Rats Sprague-Dawley Contractility Bladder outlet obstruction Adenosine Triphosphate Urethra Internal medicine Muscarinic acetylcholine receptor medicine Animals Ligation Rat Bladder Pharmacology business.industry Purinergic receptor Rats Urinary Bladder Neck Obstruction Endocrinology business Muscle Contraction medicine.drug |
| Zdroj: | Autonomic & autacoid pharmacology, 27(1), 47-53. Wiley-Blackwell |
| ISSN: | 1474-8673 1474-8665 |
| DOI: | 10.1111/j.1474-8673.2006.00393.x |
| Popis: | Summary 1 The present study was designed to investigate the relationship between innervation density and contractile responses to field stimulation and exogenous agonists at early time points after induction of bladder outlet obstruction (BOO) in rats. 2 When compared with sham-operated animals, 1, 3 and 7 days of BOO were associated with a 75%, 80% and 90% increase of bladder weight. Field stimulation caused a frequency-dependent increase in force of contraction. The force of contraction was reduced at each frequency in BOO rats with the greatest decrease after 1 day and a gradual but incomplete recovery thereafter. In contrast, contractile responses to ATP, carbachol and KCl were markedly reduced after 1 day of BOO and fully recovered after 7 days. The neurofilament staining was not altered by 1 day of BOO, but gradually decreased with increasing duration of BOO reaching the lowest levels after 7 days. 3 We conclude that impaired cellular contractility seems to underlie the early reductions of field stimulation-induced contraction, possibly reflecting surgical trauma of the tissue. However, at later time points a reduced nerve density, possibly reflecting a partial denervation, appears to be the main reason for impaired contractile response to field stimulation. |
| Databáze: | OpenAIRE |
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