An Epstein-Barr virus-producer line Akata: Establishment of the cell line and analysis of viral DNA
| Autor: | Shinichi Hayasaka, Kenzo Takada, Kenichi Horinouchi, Toyoro Osato, Motoo Takahashi, Takao Aya, Yasushi Ono |
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| Rok vydání: | 1991 |
| Předmět: |
Herpesvirus 4
Human Transforming virus Restriction Mapping Antibodies Viral medicine.disease_cause Herpesviridae Virus hemic and lymphatic diseases Virology Tumor Cells Cultured Genetics medicine Humans Gammaherpesvirinae Antigens Viral Molecular Biology Southern blot biology General Medicine biology.organism_classification medicine.disease Burkitt Lymphoma Epstein–Barr virus Blotting Southern Epstein-Barr Virus Nuclear Antigens Cell culture Child Preschool Immunoglobulin G DNA Viral Female Burkitt's lymphoma |
| Zdroj: | Virus Genes. 5:147-156 |
| ISSN: | 1572-994X 0920-8569 |
| DOI: | 10.1007/bf00571929 |
| Popis: | An Epstein-Barr virus (EBV)-producer line, designated Akata, was established from a Japanese patient with Burkitt's lymphoma. The Akata line possessed the Burkitt's-type chromosome translocation, t(8q- ; 14q+), and was derived from the tumor cell. Akata cells produced a large quantity of transforming virus upon treatment of cells with anti-immunoglobulin antibodies (Takada, 1984). Southern blot analysis of viral DNA indicated that the Akata EBV is nondefective and more representative of wild-type viruses. Akata cells should be useful as a source of EBV. |
| Databáze: | OpenAIRE |
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