Abnormal functional responses of osteoblasts to leptin in adolescent idiopathic scoliosis
| Autor: | Bobby Kw Ng, Simon Km Lee, Yong Qiu, Tsz Ping Lam, Elisa Ms Tam, Shengping Tang, Kar-Hing Yeung, Jack Cy Cheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty lcsh:Diseases of the musculoskeletal system business.industry Leptin digestive oral and skin physiology Mesenchymal stem cell Idiopathic scoliosis Bioinformatics medicine.anatomical_structure Endocrinology Energy expenditure Internal medicine Bone quality medicine Oral Presentation Orthopedics and Sports Medicine Bone marrow lcsh:RC925-935 business hormones hormone substitutes and hormone antagonists Skeletal growth |
| Zdroj: | Journal of Orthopaedic Translation, Vol 2, Iss 4, p 219 (2014) Scoliosis |
| Popis: | Objective Leptin has been postulated as one of the etiologic factors of AIS because of its important physiological functions in neuro-osseous development affecting skeletal growth, the onset of puberty, energy expenditure and body composition. Previous studies on the relationship between leptin and HR-pQCT derived bone quality parameters had found abnormal correlations in AIS girls, and suggested possible abnormalities in the leptin regulated bone metabolic pathways. Another study on AIS patients showed hyposensitivity to leptin in bone marrow derived mesenchymal stem cells This study aimed to investigate the effect of leptin on the functional responses of osteoblasts in AIS girls, and compare with that of controls. |
| Databáze: | OpenAIRE |
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