Corifollitropin alfa for poor responders patients, a prospective randomized study
| Autor: | S. Melis, M. Cappato, M. Arnoldi, Ilario Candeloro, F.M. Fusi, A. Di Pasqua, Laura Zanga |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Agonist medicine.medical_specialty Pregnancy Rate lcsh:QH471-489 medicine.drug_class Corifollitropin alfa Reproductive medicine Oocyte Retrieval Alpha (ethology) Fertilization in Vitro lcsh:Gynecology and obstetrics Poor responders Endocrinology Ovulation Induction Pregnancy Internal medicine medicine Humans lcsh:Reproduction Ovarian Reserve lcsh:RG1-991 Intention-to-treat analysis business.industry Research Antagonist Obstetrics and Gynecology medicine.disease Triptorelin Pregnancy rate Treatment Outcome Reproductive Medicine Female Follicle Stimulating Hormone Human business Infertility Female Developmental Biology medicine.drug |
| Zdroj: | Reproductive Biology and Endocrinology, Vol 18, Iss 1, Pp 1-6 (2020) Reproductive Biology and Endocrinology : RB&E |
| ISSN: | 1477-7827 |
| DOI: | 10.1186/s12958-020-00628-6 |
| Popis: | Background Poor ovarian response remains one of the biggest challenges for reproductive endocrinologists. The introduction of corifollitropin alpha (CFA) offered an alternative option to other gonadotropins for its longer half-life, its more rapid achievement of the threshold and higher FSH levels. We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol. Methods Patients enrolled fulfilled at least two of the followings: AFC 40 years. Ovarian stimulation with an antagonist protocol was performed either with 300 UI rFSH and 150 UI rLH or 300UI HMG. In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day. In the short antagonist group CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day. The primary objective was the effect on the number of oocytes and MII oocytes. Secondary objective were pregnancy rates, ongoing pregnancies and ongoing pregnancies per intention to treat. Results The use of CFA resulted in a shorter lenght of stimulation and a lower number of suspended treatments. Both the CFA protocols were significantly different from the no-CFA group in the number of retrieved oocytes (p p p Conclusions The long agonist protocol with the addition of rFSH and rLH showed the best results in all the parameters. A short antagonist protocol with CFA was less effective, but not significantly, although provided better results compared to the no-CFA group. We suggest that a long agonist protocol with CFA and recombinant gonadotropins might be a valuable option for poor responders. Trial registration The study was approved by the local Ethics Committee (EudraCT2015–002817-31). |
| Databáze: | OpenAIRE |
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