From Genome-Wide Association Studies to Cardiac Electrophysiology: Through the Maze of Biological Complexity
| Autor: | Koen T. Scholman, Veronique M. F. Meijborg, Carolina Gálvez-Montón, Elisabeth M. Lodder, Bastiaan J. Boukens |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:QP1-981 business.industry Cardiac electrophysiology Physiology Mini Review Genetic variants Genome-wide association study Computational biology 030204 cardiovascular system & hematology lcsh:Physiology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Physiology (medical) Risk stratification cardiovascular system gene expression Medicine GWAS genetics cardiovascular diseases business cardiac electrophysiology arrhythmias |
| Zdroj: | Frontiers in Physiology Frontiers in Physiology, Vol 11 (2020) |
| ISSN: | 1664-042X |
| Popis: | Genome Wide Association Studies (GWAS) have provided an enormous amount of data on genomic loci associated with cardiac electrophysiology and arrhythmias. Clinical relevance, however, remains unclear since GWAS do not provide a mechanistic explanation for this association. Determining the electrophysiological relevance of variants for arrhythmias would aid development of risk stratification models for patients with arrhythmias. In this review, we give an overview of genetic variants related to ECG intervals and arrhythmogenic pathologies and discuss how these variants may influence cardiac electrophysiology and the occurrence of arrhythmias. |
| Databáze: | OpenAIRE |
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