Telocytes contribute to aging-related modifications in the prostate
| Autor: | Rejane M. Góes, Juliana S. Maldarine, Sebastião Roberto Taboga, Maria Letícia Duarte Lima, Paula Rahal, Bruno D. A. Sanches, Guilherme Henrique Tamarindo, Hernandes F. Carvalho, Vitória Alário dos Santos, Sérgio Luis Felisbino, Alana Della Torre da Silva |
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| Přispěvatelé: | Universidade Estadual de Campinas (UNICAMP), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Senescence Pathology medicine.medical_specialty Angiogenesis Urology VEGF receptors Science Myocytes Smooth Muscle Fluorescent Antibody Technique In Vitro Techniques Biology Gerbil Article Microscopy Electron Transmission Smooth muscle Stroma Prostate medicine Animals Humans Telocytes Multidisciplinary medicine.anatomical_structure Connective Tissue biology.protein Immunohistochemistry Medicine sense organs |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020) Scientific Reports |
| Popis: | Made available in DSpace on 2021-06-25T10:46:21Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Telocytes are interstitial cells present in the stroma of several organs, including the prostate. There is evidence that these cells are present during prostate alveologenesis, in which these cells play a relevant role, but there is no information about the presence of and possible changes in telocytes during prostate aging. Throughout aging, the prostate undergoes several spontaneous changes in the stroma that are pro-pathogenic. Our study used histochemistry, 3D reconstructions, ultrastructure and immunofluorescence to compare the adult prostate with the senile prostate of the Mongolian gerbil, in order to investigate possible changes in telocytes with senescence and a possible role for these cells in the age-associated alterations. It was found that the layers of perialveolar smooth muscle become thinner as the prostatic alveoli become more dilated during aging, and that telocytes form a network that involves smooth muscle cells, which could possibly indicate a role for telocytes in maintaining the integrity of perialveolar smooth muscles. On the other hand, with senescence, VEGF+ telocytes are seen in stroma possibly contributing to angiogenesis, together with TNFR1+ telocytes, which are associated with a pro-inflammatory microenvironment in the prostate. Together, these data indicate that telocytes are important both in understanding the aging-related changes that are seen in the prostate and also in the search for new therapeutic targets for pathologies whose frequency increases with age. Department of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP), Bertrand Russel Av. Laboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265 Laboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265 Laboratory of Extracellular Matrix Institute of Biosciences São Paulo State University – UNESP, Prof. Dr. Antônio Celso Wagner Zanin St., 250, Rubião Júnior District Laboratory of Microscopy and Microanalysis Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265 Laboratory of Genome Studies Department of Biology São Paulo State University (UNESP), Cristóvão Colombo St., 2265 Laboratory of Extracellular Matrix Institute of Biosciences São Paulo State University – UNESP, Prof. Dr. Antônio Celso Wagner Zanin St., 250, Rubião Júnior District FAPESP: 2018/08945-8 |
| Databáze: | OpenAIRE |
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