Neurophysiological findings and their prognostic value in critical COVID-19 patients: An observational study
| Autor: | Saad Nseir, Philippe Derambure, Enagnon Kazali Alidjinou, Sébastien Preau, Laurence Chaton, Romain Tortuyaux, Arnaud Delval, M. Jourdain, Raphael Favory, Julien Poissy, Daniel Mathieu, Lille Intensive Care, Bruno Garcia, Jean-Paul Niguet |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Critical Care Sedation Central nervous system Encephalopathy Neurophysiology Audiology Electroencephalography Somatosensory system Article 050105 experimental psychology Arousal 03 medical and health sciences 0302 clinical medicine Evoked Potentials Somatosensory Physiology (medical) Humans Medicine 0501 psychology and cognitive sciences Evoked Potentials Aged Retrospective Studies medicine.diagnostic_test business.industry 05 social sciences COVID-19 Middle Aged Prognosis medicine.disease Sensory Systems Discontinuation Delta wave medicine.anatomical_structure Neurology Evoked Potentials Auditory Female Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Clinical Neurophysiology |
| ISSN: | 1388-2457 |
| Popis: | Objective To describe EEG patterns of critical Coronavirus Disease 2019 (COVID-19) patients with suspicion of encephalopathy and test their association with clinical outcome. Methods EEG after discontinuation of sedation in all patients, and somesthesic evoked potentials and brainstem auditive evoked potentials when EEG did not show reactivity, were performed. Clinical outcome was assessed at day 7 and 14 after neurophysiological explorations. Results 33 patients were included for analysis. We found slowed background activity in 85% of cases, unreactive activity in 42% of cases, low-voltage activity in 21% of cases and rhythmic or periodic delta waves in 61% of cases. EEG epileptic events were never recorded. Clinical outcome at day 14 was associated with unreactive background activity and tended to be associated with rhythmic or periodic delta waves and with low-voltage activity. Results of multimodal evoked potentials were in favor of a preservation of central nervous system somatosensory and auditory functions. Conclusions Among critical COVID-19 patients with abnormal arousal at discontinuation of sedation, EEG patterns consistent with encephalopathy are found and are predictive for short term clinical outcome. Significance The abnormal EEG with presence of periodic discharges and lack of reactivity could be related to encephalopathy linked to COVID-19. |
| Databáze: | OpenAIRE |
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