The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study
| Autor: | Ercan Yilmaz, Simay Gurocak, Öztun Temelli, Işıl Köleli, Rauf Melekoglu, Simge Faydali, Tuba Yar |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Brachytherapy 030204 cardiovascular system & hematology Gastroenterology Disease-Free Survival Endometrium 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Stage (cooking) Survival analysis Aged Neoplasm Staging Retrospective Studies Aged 80 and over Adjuvant radiotherapy business.industry Endometrial cancer Medical record Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Survival Analysis Endometrial Neoplasms Radiation therapy Treatment Outcome 030220 oncology & carcinogenesis Female Radiotherapy Adjuvant Neoplasm Grading Neoplasm Recurrence Local business |
| Zdroj: | Medical Science Monitor. 25:2811-2818 |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.913740 |
| Popis: | BACKGROUND This retrospective clinical study aimed to investigate the effect of prognostic factors and adjuvant radiotherapy in patients with high-grade early-stage endometrial cancer on overall survival (OS) and disease-free survival (DFS). MATERIAL AND METHODS The medical records of patients diagnosed with high-grade, early stage (I or II) endometrial adenocarcinoma who had received adjuvant radiotherapy after surgery were reviewed. RESULTS Seventy-nine patients included 39 patients (49.4%) with stage II endometrial cancer, 25 patients (31.6%) with histologic grade 3 tumors, and 47 patients (59.5%) with endometrial cancer showing lymphovascular space invasion (LVSI). There were 45 patients (57.0%) who received external pelvic radiotherapy with an average dose of 46.0 Gy (range, 11.2-50.4 Gy), and 34 patients (43.0%) received vaginal brachytherapy (VBT) with an average dose of 21.5 Gy (range, 10-36 Gy). Multivariate analysis showed that tumor stage (HR, 4.066; 95% CI, 1.227-13.467; p=0.022) and histologic grade (HR, 16.652; 95% CI, 4.430-62.589; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|