Long-Term Clinical Outcome in Familial and Sporadic Papillary Thyroid Carcinoma
| Autor: | Alessandra Cartocci, Chiara Secchi, Furio Pacini, Tania Pilli, Silvia Cantara, Lucia Brilli, Fabio Maino, Marco Capezzone, Maria Grazia Castagna, Noemi Fralassi, Raffaella Forleo, Gabriele Cevenini |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Clinical Thyroidology / Research Article business.industry Endocrinology Diabetes and Metabolism Familial papillary thyroid cancer 030209 endocrinology & metabolism Prognosis medicine.disease Papillary thyroid cancer Thyroid carcinoma 03 medical and health sciences Persistent Disease 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine Outcome Recurrences Sporadic papillary thyroid cancer medicine Clinicopathological features Initial therapy business Tumour diameter |
| Zdroj: | Eur Thyroid J |
| ISSN: | 2235-0802 2235-0640 |
| DOI: | 10.1159/000506955 |
| Popis: | Background: The definition and the behaviour of familial papillary thyroid cancer (FPTC) compared to the sporadic form (SPTC) are still debated. Some authors believe that only families with 3 or more affected members represent an actual example of familial diseases. Objectives: The objective of the study was to analyse the clinicopathological features and the outcome of sporadic and familial PTC patients also according to the number of affected members. Methods: Among 731 patients, we identified 101 (13.8%) with familial diseases, 79 with 2 affected members (FPTC-2) and 22 with 3 or more affected members (FPTC-3) followed for a mean period of 10 years. Results: FPTC patients had more frequently bilateral tumour (p = 0.007). No difference was found between the 2 groups for the other evaluated variables. At the time of the first follow-up (1–2 years after initial therapy), FPTC patients had a higher rate of persistent disease. However, at the last follow-up, the clinical outcome was not different between sporadic and familial patients. When the comparison between SPTC and FPTC was performed, according to the number of affected members, a significant trend between the 3 groups was observed for tumour diameter (p = 0.002) and bilaterality (p = 0.003), while we did not observe a significant trend for both response to initial therapy (p = 0.15) and last clinical outcome (p = 0.22). Conclusions: Our results suggest that, although the clinicopathological features of FPTC may be more aggressive, the long-term outcome is similar between FPTC and SPTC. A possible explanation is that PTC has a favourable prognosis, even when clinical presentation is more aggressive. |
| Databáze: | OpenAIRE |
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