Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome
| Autor: | Néviton Castro, Marshall J. Glesby, Davi Costa, André Luiz Muniz Alves dos Santos, Edgar Marcelino de Carvalho Filho, Isadora Cristina de Siqueira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Weakness paraparesia espástica tropical mielite Myelitis Article lcsh:RC321-571 Myelopathy myelitis Risk Factors Internal medicine Tropical spastic paraparesis medicine Humans lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry tropical spastic paraparesis Urinary bladder bexiga urinária neurogênica Urinary Bladder Overactive business.industry doenças da medula espinal Odds ratio Middle Aged Viral Load urinary bladder neurogenic medicine.disease spinal cord diseases Paraparesis Tropical Spastic Surgery Cross-Sectional Studies medicine.anatomical_structure Socioeconomic Factors Neurology Overactive bladder Regression Analysis Female Neurology (clinical) medicine.symptom business Asymptomatic carrier |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Volume: 70, Issue: 4, Pages: 252-256, Published: APR 2012 Arquivos de Neuro-Psiquiatria, Vol 70, Iss 4, Pp 252-256 (2012) Arquivos de Neuro-Psiquiatria v.70 n.4 2012 Arquivos de neuro-psiquiatria Academia Brasileira de Neurologia instacron:ABNEURO |
| Popis: | OBJECTIVE: To compare neurological symptoms and signs in HTLV-1 asymptomatic carriers and HTLV-1 patients with overactive bladder (OB) syndrome. METHODS: We studied 102 HTLV-1 positive individuals without HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis) divided into two groups according to the presence or absence of OB syndrome. Clinical interview, neurological exam and proviral load was performed in all patients. RESULTS AND CONCLUSIONS: Individuals with OB were more commonly female (84.3 vs. 60.8% of asymptomatics, p=0.01). The prevalence of neurological complaints was higher in OB group, especially hand or foot numbness and arm or leg weakness. There was no difference between the groups in neurological strength and reflexes. Weakness complaint remained strongly associated with OB in multivariate logistic regression analysis adjusting for sex and age [adjusted odds ratio and 95%CI 3.59 (1.45-8.88) in arms and 6.68 (2.63-16.93) in legs]. Proviral load was also different between the two groups with higher level on OB individuals. OBJETIVO: Comparar sintomas e sinais neurológicos em pacientes portadores do HTLV-1 assintomáticos e com síndrome de bexiga hiperativa (BH). MÉTODOS: Foram estudados 102 indivíduos com HTLV-1 sem HAM/TSP (mielopatia associada ao HTLV-I/paraparesia espástica tropical), divididos em dois grupos segundo a presença ou ausência de BH. Foram realizados em todos os pacientes entrevista clínica, exame neurológico e carga proviral. RESULTADOS E CONCLUSÕES: Indivíduos com BH foram na maioria do sexo feminino (84,3 vs. 60,8% dos assintomáticos, p=0,01). A prevalência de queixas neurológicas foi maior no grupo BH, especialmente dormências e fraqueza em extremidades. Não houve diferença entre os grupos em relação a achados do exame neurológico. Fraqueza subjetiva permaneceu fortemente associada com BH na regressão logística multivariada ajustada para sexo e idade [OR e IC95% 3,59 (1,45-8,88) nos braços e 6,68 (2,63-16,93) nas pernas]. A carga proviral foi também diferente entre os dois grupos com nível maior em indivíduos com BH. |
| Databáze: | OpenAIRE |
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