Acute and Chronic Pancreatitis in the Rat Caused by a Closed Duodenal Loop
| Autor: | R. O’Hare, S.N. Joffe, M.M. Ferrie |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Necrosis Duodenum Gastroenterology Internal medicine Ascites Acinar cell Animals Medicine Fat necrosis Pancreas Common bile duct business.industry Blood Proteins medicine.disease Rats Major duodenal papilla medicine.anatomical_structure Pancreatitis Acute Disease Amylases Chronic Disease medicine.symptom business |
| Zdroj: | Digestion. 18:280-285 |
| ISSN: | 1421-9867 0012-2823 |
| Popis: | A closed duodenal loop was created by the obstruction of the duodenum on either side of the common bile duct. Acute haemorrhagic pancreatitis developed within 24 h with interlobular oedema, marked acinar cell necrosis, intra-abdominal fat necrosis and ascites. Plasma amylase activity was greatly increased together with a marked decrease in albumin. There was a temporary abnormality of liver function tests due to obstruction of bile. When the duodenal obstruction was released and the animals allowed to survive there was at 3 weeks a marked reduction in the pancreatic acinar cells with fibrosis and areas of necrosis and chronic inflammatory cell infiltration. Plasma amylase activity was normal but there was an increase in total plasma protein at 3 weeks. This technique of a closed duodenal loop in the rat gives a simple, reliable and economic experimental model for studies on acute and chronic fibrotic pancreatitis. |
| Databáze: | OpenAIRE |
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