Her2-Positive and Microsatellite Instability Status in Gastric Cancer—Clinicopathological Implications
Autor: | Francisca Rius, Silvia Mercado, Diego Bermudez, Juan Antonio López-Villodres, María V Ortega, Virginia González, Isabel Arranz-Salas, Carmen Alba, Ana Bermúdez, Isabel Hierro |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Medicine (General) medicine.medical_treatment Clinical Biochemistry Article 03 medical and health sciences 0302 clinical medicine R5-920 Internal medicine HER2 medicine Human Epidermal Growth Factor Receptor 2 neoplasms Intestinal type Chemotherapy molecular classification business.industry gastric cancer Advanced stage Cancer Microsatellite instability Retrospective cohort study medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Clinicopathological features microsatellite instability business clinicopathological features |
Zdroj: | Diagnostics, Vol 11, Iss 944, p 944 (2021) Diagnostics Volume 11 Issue 6 |
ISSN: | 2075-4418 |
Popis: | Gastric cancer (GC) is one of the leading causes of cancer-related death. The combination of new molecular classifications with clinicopathological data could contribute to the individualization of patients and to the development of new therapeutic strategies. We examined the various associations in two molecular types of GC: HER2-positive (human epidermal growth factor receptor 2) and microsatellite instability (MSI), assessing their influence on treatment and prognosis. A retrospective study of 142 GC patients was performed with molecular characterization through HER2 overexpression and DNA repair protein expression for MSI. The percentage of HER2-positive tumors was 13.4%, predominantly in men. Correlations were found with intestinal type, metastases, advanced stages and chemotherapy. Almost 75% of HER2-positive patients died. MSI occurred in 16.2%, associated with advanced age, female sex, distal location and intestinal type. These patients had few metastases and low stages. The percentage of deaths was higher among MSI patients who received perioperative chemotherapy. The determination of HER2 and MSI status in GC is important for their association with specific clinicopathological features and for their prognostic and predictive value. |
Databáze: | OpenAIRE |
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