Role of hydrogen sulfide in cerebrovascular alteration during aging
| Autor: | Juyeon Mun, Hye-Min Kang, Chan Park, Junyang Jung |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Aging Hydrogen sulfide Central nervous system Apoptosis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Vascular Stiffness Drug Discovery Medicine Animals Humans Cognitive Dysfunction Hydrogen Sulfide Cognitive impairment Pathological Microvessel Cellular Senescence business.industry Organic Chemistry Brain equipment and supplies medicine.disease Disease Models Animal 030104 developmental biology medicine.anatomical_structure Neuroprotective Agents chemistry 030220 oncology & carcinogenesis Cerebrovascular Circulation Microvessels Arterial stiffness Molecular Medicine Endothelium Vascular business Neuroscience Signal Transduction |
| Zdroj: | Archives of pharmacal research. 42(5) |
| ISSN: | 1976-3786 |
| Popis: | Hydrogen sulfide (H2S), a gasotransmitter molecule, has attracted attention as an endogenous signaling molecule because of its various pathological and physiological effects, including pathologies related to aging. In this review, we aimed to discuss the morphological changes in each vessel following aging, and to evaluate the possible role of H2S in the cerebrovascular alteration, such as arterial stiffness, microvessel loss, and blood–brain barrier disruption, with advancing age. Additionally, the review outlines the therapeutic efficacy of the H2S-releasing compounds on the cerebrovasculature. In the central nervous system, cerebrovascular aging can lead to the loss of blood–brain integrity, which causes cognitive impairment. The findings discussed in this review strongly support the notion that H2S has a potential therapeutic role in cerebrovascular alteration in aging. |
| Databáze: | OpenAIRE |
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