Ubiquitin-conjugating enzyme UBE2C is highly expressed in breast microcalcification lesions
| Autor: | Nan Jing Peng, Jih Jung Chen, Jiin Tsuey Cheng, Chen Pin Chou, Shu Jhen Jhuang, Tsung-Hsien Chang, Chian Feng Chen, Huay Ben Pan, Nan Chieh Huang |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pathology
medicine.medical_specialty RhoC lcsh:Medicine CA 15-3 Breast Neoplasms Biology medicine.disease_cause Pathology and Laboratory Medicine CXCR4 Proto-Oncogene Mas chemistry.chemical_compound Breast Diseases Breast cancer Diagnostic Medicine Cell Line Tumor medicine Biomarkers Tumor Medicine and Health Sciences Cancer Detection and Diagnosis Humans CXC chemokine receptors Breast lcsh:Science Tumor marker Cell Proliferation Multidisciplinary lcsh:R Calcinosis Middle Aged medicine.disease Vascular endothelial growth factor chemistry Oncology Ubiquitin-Conjugating Enzymes Cancer research biology.protein lcsh:Q Female KRAS Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 4, p e93934 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Ubiquitin-conjugating enzyme 2C (UBE2C) contributes to ubiquitin-mediated proteasome degradation of cell cycle progression in breast cancer. Microcalcification (MC) is the most common mammographic feature of early breast cancer. In this study, we evaluated whether UBE2C could be a tumor marker of early breast cancer with MC found on screening mammography. UBE2C protein and mRNA expression were measured in breast core biopsy pairs of MC and adjacent non-MC breast tissue from each subject. Immunohistochemistry revealed UBE2C positivity in 69.4% of MC samples and 77.6% negativity in non-MC samples (p |
| Databáze: | OpenAIRE |
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