Family history of Type 1 diabetes affects insulin secretion in patients with ‘Type 2’ diabetes
| Autor: | Boris Isomaa, Virve M. Lundgren, Tiinamaija Tuomi, Mette K. Andersen |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Endocrinology Diabetes and Metabolism Type 2 diabetes Endocrinology HLA Antigens Internal medicine Diabetes mellitus Insulin Secretion Internal Medicine medicine Humans Insulin Mass Screening Genetic Predisposition to Disease Family history Finland Mass screening Glucose tolerance test Type 1 diabetes C-Peptide medicine.diagnostic_test Glutamate Decarboxylase business.industry Insulin tolerance test Autoantibody Glucose Tolerance Test Middle Aged medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Phenotype Diabetes Mellitus Type 2 Female business |
| Zdroj: | Diabetic Medicine. 30:e163-e169 |
| ISSN: | 0742-3071 |
| DOI: | 10.1111/dme.12069 |
| Popis: | Aims The aim was to evaluate the impact of family history of diabetes on the phenotype of patients diagnosed with Type 2 diabetes and the frequency of susceptibility genotypes. Methods Patients with Type 2 diabetes with family history for both Type 1 and Type 2 diabetes (FHMIX, n = 196) or Type 2 diabetes only (FHT2, n = 139) matched for age, sex, BMI and age at diagnosis, underwent an oral glucose tolerance test and a combined glucagon test and insulin tolerance test. Glutamic acid decarboxylase (GAD) antibodies and major Type 1 and Type 2 diabetes susceptibility gene variants were analysed. Patients were stratified into groups according to family history or GAD antibody positivity (GADA+, GADA–) or a combination of these (GADA+/FHMIX, GADA+/FHT2, GADA–/FHMIX, GADA–/FHT2). Results Compared with other patients, those with FHMIX more often had GAD antibodies (14.3 vs. 4.3%, P = 0.003), and those with both FHMIX and GAD antibodies had the highest frequency of insulin deficiency (stimulated serum C-peptide |
| Databáze: | OpenAIRE |
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