Patterning of Cantilevers with Functionalized Nanoparticles for Combinatorial Atomic Force Microscopy

Autor:	Roderick A. Chisholm, John-Bruce D. Green, Wally Qiu
Rok vydání:	2007
Předmět:	Functionalized nanoparticles Cantilever Chemistry Atomic force microscopy Electrochemistry Nanoparticle General Materials Science Nanotechnology Surfaces and Interfaces Condensed Matter Physics Spectroscopy
Zdroj:	Langmuir. 23:7891-7894
ISSN:	1520-5827 0743-7463
Popis:	In this letter, we demonstrate a substantial improvement in the ease of attaching and recognizing chemical libraries on cantilevers for use with combinatorial atomic force microscopy. These experiments exploit chemically modified nanoparticles as a means of encoding various chemistries onto the cantilevers with structures that can be readily distinguished. For the first time, 16 combinations of interactions were measured in a single experiment and in the same solution. Furthermore, these experiments have not begun to push the limits of the technique; it is plausible that in the very near future hundreds of interactions could be rapidly measured, helping to transform AFM into a truly high throughput technique.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e6258b734cba4f20dffd862b1048e8 https://doi.org/10.1021/la700397u Zobrazit plný text záznamu