Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand
| Autor: | Natthawut Kaewpitoon, Soraya J Kaewpitoon, Taweesak Tongtawee, Ryan A Loyd, Wilairat Leeanansaksiri, Likit Matrakool, Chavaboon Dechsukhum, Sukij Panpimanmas |
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| Rok vydání: | 2016 |
| Předmět: |
Adenoma
Adult Male Cancer Research medicine.medical_specialty Adolescent Epidemiology Colorectal cancer Colonoscopy Rapid urease test Gastroenterology Helicobacter Infections Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Helicobacter Risk factor Aged Helicobacter pylori biology medicine.diagnostic_test business.industry Public Health Environmental and Occupational Health Intestinal Polyps Middle Aged Thailand medicine.disease biology.organism_classification Cross-Sectional Studies Oncology Dysplasia Gastritis 030220 oncology & carcinogenesis Female 030211 gastroenterology & hepatology medicine.symptom Colorectal Neoplasms business |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 17:341-345 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2016.17.1.341 |
| Popis: | Background: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. Materials and Methods: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. Results: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. Conclusions: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer. |
| Databáze: | OpenAIRE |
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