Salivary Oxidative Stress Increases With the Progression of Chronic Heart Failure
| Autor: | Robert Sawicki, Mateusz Maciejczyk, Małgorzata Knapp, Anna Zalewska, Anna Klimiuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Saliva
medicine.medical_specialty Antioxidant medicine.medical_treatment Saliva secretion lcsh:Medicine 030204 cardiovascular system & hematology medicine.disease_cause Article Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine salivary biomarkers Internal medicine medicine oxidative stress 030304 developmental biology chemistry.chemical_classification 0303 health sciences Reactive oxygen species saliva biology business.industry lcsh:R General Medicine Malondialdehyde chronic heart failure Endocrinology chemistry biology.protein Uric acid business Oxidative stress |
| Zdroj: | Journal of Clinical Medicine Volume 9 Issue 3 Journal of Clinical Medicine, Vol 9, Iss 3, p 769 (2020) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm9030769 |
| Popis: | The aim of the study was to evaluate the rate of reactive oxygen species (ROS) production, antioxidant barrier, and oxidative damage in non-stimulated (NWS) and stimulated (SWS) saliva as well as plasma/erythrocytes of 50 patients with chronic heart failure (HF) divided into the two subgroups: NYHA II (33 patients) and NYHA III (17 patients). The activity of superoxide dismutase and catalase was statistically increased in NWS of HF patients as compared to healthy controls. The free radical formation, total oxidant status, level of uric acid, advanced glycation end products (AGE), advanced oxidation protein products and malondialdehyde was significantly elevated in NWS, SWS, and plasma of NYHA III patients as compared to NYHA II and controls. We were the first to demonstrate that with the progression of HF, disturbances of enzymatic and non-enzymatic antioxidant defense, and oxidative damage to proteins and lipids occur at both central (plasma/erythrocytes) and local (saliva) levels. In the study group, we also observed a decrease in saliva secretion, total salivary protein and salivary amylase activity compared to age- and gender-matched control group, which indicates secretory dysfunction of salivary glands in patients with HF. Salivary AGE may be a potential biomarker in differential diagnosis of HF. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |