HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis

Autor:	Gilles Edan, Marie-Claude Babron, M. Rosenheim, Bertrand Fontaine, Hervé Perdry, Gout C, Mehdi Alizadeh, J. Yaouanq, Emmanuelle Leray, Gilbert Semana, Emmanuelle Génin, Françoise Clerget-Darpoux, David Brassat, Cournu-Rebeix I, Jérémie F. Cohen
Rok vydání:	2008
Předmět:	Adult Male Multiple Sclerosis Adolescent Multiple sclerosis Immunology HLA-DR Antigens Disease Human leukocyte antigen Biology medicine.disease Natural history Relapsing remitting Genotype Genetics medicine Humans Female Allele Child HLA-DRB1 Genetics (clinical) HLA-DRB1 Chains
Zdroj:	Genes & Immunity. 9:570-574
ISSN:	1476-5470 1466-4879
Popis:	Most of the published works so far have aimed at finding genes associated with multiple sclerosis (MS) susceptibility. Very few studies have attempted to correlate disease features with DNA variants. In a well-characterized sample (651 patients) representative of multiple sclerosis natural history, we engaged a comprehensive study of the role of human leukocyte antigen (HLA) in the course of the disease. We investigated the role of HLA-DRB1*15 allele in samples stratified according to severity evaluated by the Multiple Sclerosis Severity Score (MSSS), time to reach EDSS 6.0 and disease type. We found that HLA-DRB1*15 genotype does not influence MS severity even among patients presenting with a given type of the disease. However, we show for the first time that HLA-DRB1*15 allele modulates the course of MS for relapsing-remitting (RR) onset patients likely by precipitating the secondary progressive (SP) phase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ce8504a27a647aa7c5abd06291d184 https://doi.org/10.1038/gene.2008.52 Zobrazit plný text záznamu Plný text ve formátu PDF