Predictors of Chemotherapy Induced Adverse Events in Pediatric Osteosarcoma Patients
| Autor: | Phitjira Sanguanboonyaphong, Patcharee Komvilaisak, Kunanya Suwannaying, Jukapun Yoodee, Manit Saeteaw, Suthan Chanthawong, Suphat Subongkot |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Osteosarcoma Neutropenia Adolescent Drug-Related Side Effects and Adverse Reactions Vomiting Infant Newborn Infant Antineoplastic Agents Bone Neoplasms Nausea Organism Hydration Status General Medicine Thailand Thrombocytopenia Cross-Sectional Studies Methotrexate Child Preschool Odds Ratio Prevalence Humans Female Chemical and Drug Induced Liver Injury Child Retrospective Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 23(1) |
| ISSN: | 2476-762X |
| Popis: | To investigate the prevalence of chemotherapy-induced adverse events and the associated risk factors in pediatric patients with osteosarcoma.This retrospective cross-sectional study enrolled 90 pediatric osteosarcoma patients (with 1,017 chemotherapy cycles) treated at Srinagarind Medical Center, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, between January 1, 2008 and December 31, 2018. The prevalence of major adverse events and a correlation between baseline characteristics and adverse events were analyzed using a generalized estimating equation model.The prevalence of adverse events in 90 pediatric osteosarcoma patients (with 1,017 chemotherapy cycles) was determined as chemotherapy-induced nausea and vomiting (29.2%; n=296), hepatotoxicity (21.2%; n=215), anemia (70.69%; n=719), neutropenia (26.65%; n=271), and thrombocytopenia (13.65%; n=139). Factors associated with chemotherapy-induced hepatotoxicity included methotrexate dose ≥ 12 g/mMajor adverse events are becoming more common in pediatric osteosarcoma patients, and risk factors include larger chemotherapy doses, higher plasma methotrexate concentrations, and a slower pre-hydration rate. The outcomes of the study could aid in the better treatment of toxicity in children with osteosarcoma. |
| Databáze: | OpenAIRE |
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