One or two ligatures inducing periodontitis are sufficient to cause fatty liver
| Autor: | Even-Herlany-Pereira Alves, Jand-Venes-Rolim Medeiros, Felipe Rodolfo Pereira da Silva, Daniel Fernando Pereira Vasconcelos, Joaquina-dos Santos Carvalho, Francisca-Beatriz-de Melo Sousa, Victor-Brito-Dantas Martins, Luiz Felipe de Carvalho França, Jefferson Soares de Oliveira, Karina-Oliveira Drumond, David Di Lenardo, Larissa-dos Santos Pessoa |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Animals Rats Wistar Periodontitis Ligature Ligation General Dentistry Dental alveolus Oral Medicine and Pathology biology Cholesterol business.industry Research Fatty liver 030206 dentistry medicine.disease Malondialdehyde CIENCIAS MÉDICAS [UNESCO] Rats Fatty Liver Otorhinolaryngology chemistry Myeloperoxidase UNESCO::CIENCIAS MÉDICAS biology.protein Female 030211 gastroenterology & hepatology Surgery Steatosis business |
| Zdroj: | Pessoa, Larissa-dos Santos ; da Silva, Felipe Rodolfo Pereira ; Alves, Even-Herlany-Pereira ; de Carvalho França, Luiz Felipe ; di Lenardo, David ; Carvalho, Joaquina-dos Santos ; Martins, Victor-Brito-Dantas ; Sousa, Francisca-Beatriz-de Melo ; Drumond, Karina-Oliveira ; Medeiros, Jand-Venes-Rolim ; de Oliveira, Jefferson-Soares ; Vasconcelos, Daniel Fernando Pereira . One or two ligatures inducing periodontitis are sufficient to cause fatty liver. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 23 3 2018: 4 RODERIC. Repositorio Institucional de la Universitat de Valéncia instname Medicina Oral, Patología Oral y Cirugía Bucal |
| Popis: | Background Periodontitis is a chronic disease that due to an intense inflammatory response triggers systemic changes such as hepatic alterations. This study aimed to compare hepatic damage in rats that received experimental periodontitis at one or two periodontal sites with ligatures. Material and Methods Eighteen rats were separated into three groups: control, without ligature; periodontitis 1, with one ligature; and periodontitis 2, with two ligatures. The following parameters were assessed: gingival bleeding index, probing pocket depth, tooth mobility, alveolar bone loss, malondialdehyde (MDA) and myeloperoxidase (MPO) activity in periodontal tissue; histopathological evaluation of hepatic tissue (steatosis score); glutathione levels (GSH), MDA, MPO, cholesterol and triglycerides in the liver; and serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Results Periodontal evaluation data showed that the periodontitis model worked well. The groups with periodontitis did not differ significantly in relation to MPO activity and MDA levels in the gingival samples, but they were significantly different when compared with the control group. Steatosis was observed in the histological analysis of the groups with periodontitis, but between the periodontitis groups, two ligatures did not cause increase in steatosis score. The levels of GSH, MDA, total cholesterol and triglycerides in the hepatic tissue were not altered between groups with periodontitis, but they showed significant differences in comparison with the control group. The activity of MPO in hepatic tissue and serum levels of AST and ALT did not present significant difference among the three groups. Conclusions In conclusion, our results demonstrated that one or two ligatures inducing periodontitis were both sufficient to cause fatty liver. Steatosis caused by two ligatures did not present larger extension and severity than steatosis caused by one ligature. Key words:Antioxidant, anti-inflammatory agents, experimental design, periodontal disease, periodontal medicine. |
| Databáze: | OpenAIRE |
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