Review of rodent models of attention deficit hyperactivity disorder
| Autor: | Michael T. Williams, Charles V. Vorhees, Samantha L. Regan |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience Rodentia Biology Article Nicotine Mice Behavioral Neuroscience Neurodevelopmental disorder Rats Inbred SHR Internal medicine Genetic model Genetic predisposition medicine Animals Humans Attention deficit hyperactivity disorder Spontaneous hypertensive rat Dopamine transporter Behavior Animal Models Theoretical medicine.disease Rats Disease Models Animal Neuropsychology and Physiological Psychology Endocrinology Attention Deficit Disorder with Hyperactivity Dopamine receptor biology.protein medicine.drug |
| Zdroj: | Neurosci Biobehav Rev |
| ISSN: | 0149-7634 |
| Popis: | Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder that affects 8-12 % of children and4 % of adults. Environmental factors are believed to interact with genetic predispositions to increase susceptibility to ADHD. No existing rodent model captures all aspects of ADHD, but several show promise. The main genetic models are the spontaneous hypertensive rat, dopamine transporter knock-out (KO) mice, dopamine receptor subtype KO mice, Snap-25 KO mice, guanylyl cyclase-c KO mice, and latrophilin-3 KO mice and rats. Environmental factors thought to contribute to ADHD include ethanol, nicotine, PCBs, lead (Pb), ionizing irradiation, 6-hydroxydopamine, neonatal hypoxia, some pesticides, and organic pollutants. Model validation criteria are outlined, and current genetic models evaluated against these criteria. Future research should explore induced multiple gene KOs given that ADHD is polygenic and epigenetic contributions. Furthermore, genetic models should be combined with environmental agents to test for interactions. |
| Databáze: | OpenAIRE |
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