Burden of Placental Malaria among Pregnant Women Who Use or Do Not Use Intermittent Preventive Treatment at Mulago Hospital, Kampala
| Autor: | Josaphat Byamugisha, Celestino Obua, Charles O Odongo, Michael Odida, Henry Wabinga |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Pediatrics Article Subject Epidemiology 030231 tropical medicine Malaria in pregnancy lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine parasitic diseases Medicine lcsh:RC109-216 030212 general & internal medicine Pregnancy outcomes Pregnancy business.industry Obstetrics Incidence (epidemiology) medicine.disease 3. Good health Placental infection Infectious Diseases business Malaria Cohort study Research Article |
| Zdroj: | Malaria Research and Treatment, Vol 2016 (2016) Malaria Research and Treatment |
| ISSN: | 2090-8075 |
| DOI: | 10.1155/2016/1839795 |
| Popis: | Intermittent preventive treatment of malaria in pregnancy with sulphadoxine-pyrimethamine (SP-IPTp) is widely used to reduce the incidence of adverse pregnancy outcomes. As a monitor for continued effectiveness of this intervention amidst SP resistance, we aimed to assess malaria burden among pregnant women who use or do not use SP-IPTp. In a descriptive cohort study at Mulago Hospital, Kampala, 87 women who received two supervised doses of SP-IPTp were followed up until delivery. Controls were pregnant women presenting in early labour without history of SP-IPTp. Histopathological investigation for placental malaria (PM) was performed using the Bulmer classification criterion. Thirty-eight of the 87 women returned for delivery and 33 placentas were successfully collected and processed along with 33 placentas from SP nonusers. Overall, 12% (4/33) of the users had evidence of PM compared to 48% (16/33) of nonusers. Among nonusers, 17/33, 8/33, 2/33, and 6/33 had no placental infection, active infection, active-chronic infection, and past-chronic infection, respectively. Among users, respective proportions were 29/33, 2/33, 0/33, and 2/33. No difference in birth weights was apparent between the two groups, probably due to a higher proportion of infections occurring later in pregnancy. Histological evidence here suggests that SP continues to offer substantial benefit as IPTp. |
| Databáze: | OpenAIRE |
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