Effect of spleen cell populations on resolution of Cryptosporidium parvum infection in SCID mice
| Autor: | P H Mason, C E Chrisp, Lance E. Perryman |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male Ratón CD8 Antigens T-Lymphocytes Immunology Cryptosporidiosis Spleen Mice SCID Scid mice Microbiology Mice parasitic diseases medicine Animals Cryptosporidium parvum Mice Inbred BALB C biology Inoculation T lymphocyte biology.organism_classification Virology Infectious Diseases medicine.anatomical_structure Protozoa Parasitology CD8 Research Article |
| Zdroj: | Infection and Immunity. 62:1474-1477 |
| ISSN: | 1098-5522 0019-9567 |
| Popis: | Persistent infection was established in SCID mice given 10(7) Cryptosporidium parvum oocysts. Nine groups of infected SCID mice were inoculated with 10(6), 10(5), or 10(4) total spleen cells, CD8-depleted spleen cells, or CD4-depleted spleen cells from naive BALB/c donors. Infection was significantly reduced in all treatment groups. The most profound effect occurred with spleen cell preparations containing CD4 T lymphocytes but depleted of CD8 T lymphocytes. |
| Databáze: | OpenAIRE |
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