Comparison of two combined antiretroviral treatment regimens in the management of HIV in pregnancy: an observational study
| Autor: | Karl E. Seif, Jenny Q. Wang, Nina K. Sublette, Rosana Salama, Luis M. Gomez, Marcella Rodriguez, Mary E. Christiansen, Danielle L. Tate, Fernand Samson |
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| Rok vydání: | 2019 |
| Předmět: |
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Integrase inhibitor HIV Infections Nucleoside Reverse Transcriptase Inhibitor 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Antiretroviral treatment Humans Protease inhibitor (pharmacology) Prospective Studies 030212 general & internal medicine 030219 obstetrics & reproductive medicine biology business.industry Infant Obstetrics and Gynecology HIV Protease Inhibitors Viral Load medicine.disease Virology Infectious Disease Transmission Vertical Integrase Pediatrics Perinatology and Child Health biology.protein Reverse Transcriptase Inhibitors Female Observational study business |
| Zdroj: | The Journal of Maternal-Fetal & Neonatal Medicine. 34:3723-3729 |
| ISSN: | 1476-4954 1476-7058 |
| DOI: | 10.1080/14767058.2019.1691987 |
| Popis: | Combined antiretroviral therapy (cART) in pregnancy traditionally included two nucleoside reverse transcriptase inhibitors plus 1 protease inhibitor (PI). Recently, integrase strand transfer inhibitors (INSTI) have been approved for use in pregnancy. We sought to compare the rate of undetectable VL near delivery in pregnant HIV-infected women receiving INSTI-based versus PI-based cART.Prospective cohort study (January 2010-March 2017) of pregnant HIV-infected pregnancies receiving care in a single obstetric infectious disease clinic. Included pregnancies (total = 171; INSTI - group = 111, PI - group = 60) had at least 2 VL (before and after intervention) during pregnancy. The primary outcome was the rate of undetectable VL near delivery.We found comparable rates of undetectable HIV VL near delivery in pregnancies treated with INSTI-cART (74/111, 66.7%) compared to PI-cART (34/60, 56.7%; [adjustedPregnant HIV-infected women receiving either INSTI- or PI-based cART achieved comparable rates of undetectable HIV VL near delivery with similar perinatal transmission. |
| Databáze: | OpenAIRE |
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