Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites
| Autor: | Marcin Włodarczyk, Anna Krokos, Arkadiusz J. Antończak, Magdalena Kobielarz, Przemysław Płociński, Karolina Rudnicka, Milena Morawiak, Małgorzata Gazińska, Paulina Skibińska, Bogusz Stępak |
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| Rok vydání: | 2020 |
| Předmět: |
Materials science
Surface Properties Polyesters Infrared spectroscopy Biocompatible Materials 02 engineering and technology Polyethylene glycol 010402 general chemistry 01 natural sciences Catalysis Article law.invention Inorganic Chemistry lcsh:Chemistry Crystallinity chemistry.chemical_compound stomatognathic system law Materials Testing Spectroscopy Fourier Transform Infrared Physical and Theoretical Chemistry Crystallization Composite material Molecular Biology lcsh:QH301-705.5 Spectroscopy biocomposites Organic Chemistry Plasticizer Temperature biosafety General Medicine Adhesion 021001 nanoscience & nanotechnology 0104 chemical sciences Computer Science Applications Durapatite chemistry lcsh:Biology (General) lcsh:QD1-999 l-lysine hydroxyapatite surface biofunctionalization Surface modification 0210 nano-technology Glass transition monocytes |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 6711, p 6711 (2020) Volume 21 Issue 18 |
| ISSN: | 1422-0067 |
| Popis: | Novel biocomposites of poly(L-lactide) (PLLA) and poly(l-lactide-co-glycolide) (PLLGA) with 10 wt.% of surface-modified hydroxyapatite particles, designed for applications in bone tissue engineering, are presented in this paper. The surface of hydroxyapatite (HAP) was modified with polyethylene glycol by using l-lysine as a linker molecule. The modification strategy fulfilled two important goals: improvement of the adhesion between the HAP surface and PLLA and PLLGA matrices, and enhancement of the osteological bioactivity of the composites. The surface modifications of HAP were confirmed by attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), TGA, and elemental composition analysis. The influence of hydroxyapatite surface functionalization on the thermal and in vitro biological properties of PLLA- and PLLGA-based composites was investigated. Due to HAP modification with polyethylene glycol, the glass transition temperature of PLLA was reduced by about 24.5 ° C, and melt and cold crystallization abilities were significantly improved. These achievements were scored based on respective shifting of onset of melt and cold crystallization temperatures and 1.6 times higher melt crystallization enthalpy compared with neat PLLA. The results showed that the surface-modified HAP particles were multifunctional and can act as nucleating agents, plasticizers, and bioactive moieties. Moreover, due to the presented surface modification of HAP, the crystallinity degree of PLLA and PLLGA and the polymorphic form of PLLA, the most important factors affecting mechanical properties and degradation behaviors, can be controlled. |
| Databáze: | OpenAIRE |
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