Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole
| Autor: | Sara B. Honorato, Alcemira C. Oliveira, Nubia Boechat, Jorge S. Mendonça, Josué Mendes Filho, Javier Ellena, Alejandro Ayala |
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| Rok vydání: | 2014 |
| Předmět: |
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Molecular Drug Chagas disease Spectrophotometry Infrared Stereochemistry Trypanosoma cruzi media_common.quotation_subject Infrared spectroscopy Hot stage microscopy Crystallography X-Ray Analytical Chemistry chemistry.chemical_compound medicine Humans Chagas Disease Instrumentation Spectroscopy media_common biology PLANEJAMENTO DE FÁRMACOS medicine.disease biology.organism_classification Trypanocidal Agents Combinatorial chemistry Atomic and Molecular Physics and Optics Polymorphism (materials science) chemistry Nitroimidazoles Benznidazole Acetamide medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1386-1425 |
| Popis: | Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite the fact that this drug was released more than 30 years ago, little information about its solid state properties is available in the literature. In this study, it was verified that this drug exhibits three polymorphs, which were characterized in situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs were also discussed. |
| Databáze: | OpenAIRE |
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