Regenerative effect of platelet-rich fibrin on articular cartilage defects in an experimental rat model
| Autor: | Hasan Metineren, Turan Cihan Dülgeroğlu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
0106 biological sciences medicine.medical_specialty Rat model Articular cartilage 01 natural sciences Fibrin 03 medical and health sciences 0302 clinical medicine Health Care Sciences and Services Articular cartilage chondral healing experimental rat model hyaline cartilage platelet-rich fibrin 010608 biotechnology medicine Sağlık Bilimleri ve Hizmetleri 030203 arthritis & rheumatology biology business.industry Hyaline cartilage Cartilage General Engineering Platelet-rich fibrin Surgery medicine.anatomical_structure biology.protein Joint cartilage Left knee joint business |
| Zdroj: | Volume: 5, Issue: 2 299-305 The European Research Journal |
| ISSN: | 2149-3189 |
| DOI: | 10.18621/eurj.373385 |
| Popis: | Objectives: Different materials are currently being used experimentally to accelerate cartilage healing and to obtain hyaline cartilage. We aimed to investigate the effect of platelet-rich fibrin on joint cartilage healing. Methods: Twenty rats were used in this study. platelet-rich fibrin was obtained from 4 rats, and the remaining 16 rats were randomly divided into two groups (4 and 8 weeks). Both knee joints were prepared, and an osteochondral defect was created at the femoral condyle in all rats. platelet-rich fibrin was placed into the osteochondral defect of the right knee, while the left knee joint was used as a control. Groups were sacrificed after 4 and 8 weeks, respectively. Results: According to the O'Driscoll score, there were no significant differences between the right and left knee scores in group 4 weeks (p = 0.820). However, the right knee scores were significantly different than the left knee scores in group 8 weeks (p < 0.001). Defects were completely filled with cartilage tissue after 8 weeks in the platelet-rich fibrin group. Conclusions: Similar to its role in various tissues, platelet-rich fibrin is an effective biomaterial that enhances the healing of osteochondral defects. |
| Databáze: | OpenAIRE |
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