Differences in the emergent coding properties of cortical and striatal ensembles
| Autor: | Anthony G. Phillips, Adrian J. Lindsay, Liya Ma, Jeremy K. Seamans, James M. Hyman |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Dorsum Patch-Clamp Techniques business.product_category Striatum Cognitive neuroscience Gyrus Cinguli Article 03 medical and health sciences 0302 clinical medicine medicine Animals Rats Long-Evans Anterior cingulate cortex 030304 developmental biology Neurons 0303 health sciences Lever Behavior Animal General Neuroscience Rats Neostriatum Brain region medicine.anatomical_structure Conditioning Operant Psychology business Neuroscience Psychomotor Performance 030217 neurology & neurosurgery Decoding methods Coding (social sciences) |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn.3753 |
| Popis: | The function of a given brain region is often defined by the coding properties of its individual neurons, yet how this information is combined at the ensemble level is an equally important consideration. In the present study, multiple neurons from the anterior cingulate cortex (ACC) and the dorsal striatum (DS) were recorded simultaneously as rats performed different sequences of the same three actions. Sequence and lever decoding was remarkably similar on a per-neuron basis in the two regions. At the ensemble level, sequence-specific representations in the DS appeared synchronously but transiently along with the representation of lever location, while these two streams of information appeared independently and asynchronously in the ACC. As a result the ACC achieved superior ensemble decoding accuracy overall. Thus, the manner in which information was combined across neurons in an ensemble determined the functional separation of the ACC and DS on this task. |
| Databáze: | OpenAIRE |
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