Understanding the Enhanced Magnetic Response of Aminocholesterol Doped Lanthanide-Ion-Chelating Phospholipid Bicelles
| Autor: | Erich J. Windhab, Lukas D. Schuler, Peter Walde, Simon Kuster, Sarah Massabni, Marina Sturm, Joachim Kohlbrecher, Peter Fischer, Stéphane Isabettini |
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| Rok vydání: | 2017 |
| Předmět: |
Lanthanide
Magnetic Resonance Spectroscopy Lipid Bilayers Phospholipid Analytical chemistry 02 engineering and technology Model lipid bilayer 010402 general chemistry 01 natural sciences Lanthanoid Series Elements Ion chemistry.chemical_compound Magnetics Monolayer Electrochemistry Molecule General Materials Science Spectroscopy Phospholipids Chelating Agents Chemistry Bilayer Surfaces and Interfaces 021001 nanoscience & nanotechnology Condensed Matter Physics Magnetic susceptibility 0104 chemical sciences bicelles forever Crystallography Cholesterol 0210 nano-technology |
| Zdroj: | Langmuir, 33 (34) |
| ISSN: | 1520-5827 |
| Popis: | Cholesterol (Chol-OH) and its conjugates are powerful molecules for engineering the physicochemical and magnetic properties of phospholipid bilayers in bicelles. Introduction of aminocholesterol (3β-amino-5-cholestene, Chol-NH2) in bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the thulium-ion-chelating phospholipid 1,2-dimyristoyl-sn-glycero-3-phospho-ethanolamine-diethylene triaminepentaacetate (DMPE-DTPA/Tm3+) results in unprecedented high magnetic alignments by selectively tuning the magnetic susceptibility Δχ of the bilayer. However, little is known on the underlying mechanisms behind the magnetic response and, more generally, on the physicochemical forces governing a Chol-NH2 doped DMPC bilayer. We tackled this shortcoming with a multiscale bottom-up comparative investigation of Chol-OH and Chol-NH2 mixed with DMPC. First, simplified monolayer models on a Langmuir trough were employed to compare the two steroid molecules at various contents in DMPC. In a second step, a m... |
| Databáze: | OpenAIRE |
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