A link between hepatic glucose production and peripheral energy metabolism via hepatokines
| Autor: | Amandine Gautier-Stein, Sylvie Casteras, Jean-André Tourette, Carine Zitoun, Blandine Gri, Maud Soty, Caroline Romestaing, Aya Abdul-Wahed, Anne Sardella, Nicolas Pleche, Gilles Mithieux, Fabienne Rajas, Damien Roussel, Hervé Guillou |
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| Přispěvatelé: | University of Aleppo [Aleppo], Nutrition et cerveau (U1213, U855), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Ecologie des Hydrosystèmes Naturels et Anthropisés (LEHNA), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Centre National de la Recherche Scientifique (CNRS), Toxicologie Intégrative & Métabolisme (ToxAlim-TIM), ToxAlim (ToxAlim), Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, research grants from the 'Fondation pour la Recherche Médicale' (grant number DRM20101220448), 'Société francophone du diabète' (Alfediam/BMS2008 and SFD/Takeda 2010), Ministry of Higher Education of the Syrian Arab Republi, 'Fondation pour la Recherche Médicale' (grant number FDT 20111223289), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Di Carlo, Marie-Ange |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
KEY WORDS: liver
medicine.medical_specialty obesity FGF21 Biodiversité et Ecologie Glucose uptake 030209 endocrinology & metabolism Type 2 diabetes Carbohydrate metabolism Biodiversity and Ecology 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus medicine [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Molecular Biology energy expenditure 030304 developmental biology 0303 health sciences hepatokines business.industry Cell Biology medicine.disease 3. Good health Endocrinology Liver Original Article Energy expenditure [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] type 2 diabetes business Thermogenesis endogenous glucose production Endogenous glucose production Hepatokines Obesity Hormone |
| Zdroj: | Molecular metabolism Molecular metabolism, Elsevier, 2014, 3 (5), pp.531-543. ⟨10.1016/j.molmet.2014.05.005⟩ Molecular metabolism, Elsevier, 2014, 3, pp.531-543. ⟨10.1016/j.molmet.2014.05.005⟩ Molecular Metabolism 5 (3), 531-543. (2014) Molecular Metabolism Molecular metabolism, 2014, 3 (5), pp.531-543. ⟨10.1016/j.molmet.2014.05.005⟩ |
| ISSN: | 2212-8778 |
| DOI: | 10.1016/j.molmet.2014.05.005⟩ |
| Popis: | International audience; ABSTRACTType 2 diabetes is characterized by a deterioration of glucose tolerance, which associates insulinresistance of glucose uptake by peripheral tissues and increased endogenous glucose production.Here we report that the specific suppression of hepatic glucose production positively modulateswhole-body glucose and energy metabolism. We used mice deficient in liver glucose-6 phosphatasethat is mandatory for endogenous glucose production. When they were fed a high fat/high sucrosediet, they resisted the development of diabetes and obesity due to the activation of peripheralglucose metabolism and thermogenesis. This was linked to the secretion of hepatic hormones likefibroblast growth factor 21 and angiopoietin-like factor 6. Interestingly, the deletion of hepaticglucose-6 phosphatase in previously obese and insulin-resistant mice resulted in the rapidrestoration of glucose and body weight controls. Therefore, hepatic glucose production is anessential lever for the control of whole-body energy metabolism during the development of obesityand diabetes. |
| Databáze: | OpenAIRE |
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