Overview and Lessons From the Preclinical Chemoradiotherapy Testing Consortium
| Autor: | Michael Graham Espey, Bhadrasain Vikram, Eric J. Bernhard, Jeffrey C. Buchsbaum, C. Norman Coleman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty Radiation business.industry Standard treatment Cancer Antineoplastic Agents Chemoradiotherapy medicine.disease Preclinical data Clinical trial Combined modality Oncology Cancer Therapy Evaluation Program Neoplasms medicine Humans Radiology Nuclear Medicine and imaging Medical physics Head and neck business |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 111:1126-1130 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/j.ijrobp.2021.07.1709 |
| Popis: | Purpose: In the current molecular-targeted cancer treatment era, many new agents are being developed so that optimizing therapy with a combination of radiation and drugs is complex. The use of emerging laboratory technologies to further biological understanding of drug-radiation mechanisms of action will enhance the efficiency of the progression from preclinical studies to clinical trials. In 2017, the National Cancer Institute (NCI) solicited proposals through PAR 16-111 to conduct preclinical research combining targeted anticancer agents in the Cancer Therapy Evaluation Program's portfolio with chemoradiation. Methods and Materials The Preclinical Chemo-Radiotherapy Testing Consortium (PCRTC) was formed with 4 U01 programs supported to generate validated high-quality preclinical data on the effects of molecular therapeutics when added to standard-of-care therapies with a concentration on cancers of the pancreas, lung, head and neck, gastrointestinal tract, and brain. Results The PCRTC provides a rational basis for prioritizing NCI-supported investigational new drugs or agents most likely to have clinical activity with chemoradiotherapy and accelerate the pace at which combined modality treatments with greater efficacy are identified and incorporated into standard treatment practices. Conclusions Herein, we introduce and summarize the course of the PCRTC to date and report 3 preliminary observations from the consortium's work to date. |
| Databáze: | OpenAIRE |
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