Role of nitric oxide and prostaglandins in sucralfate-induced gastroprotection
| Autor: | Stanislaw J. Konturek, K. Czarnobilski, Jolanta Majka, Tomasz Brzozowski |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
medicine.medical_specialty Nocloprost Sucralfate medicine.medical_treatment Indomethacin Arginine Nitric Oxide Nitroarginine Nitric oxide chemistry.chemical_compound Internal medicine medicine Gastric mucosa Animals Stomach Ulcer Pharmacology Ethanol Stomach Rats Inbred Strains Anti-Ulcer Agents Rats medicine.anatomical_structure Endocrinology chemistry Mechanism of action Regional Blood Flow Prostaglandins F Synthetic Prostaglandins medicine.symptom Prostaglandin E medicine.drug |
| Zdroj: | European Journal of Pharmacology. 211:277-279 |
| ISSN: | 0014-2999 |
| Popis: | We investigated the role of nitric oxide (NO) and prostaglandins (PG) in the prevention by sucralfate of ethanol-induced gastric damage and the decrease of gastric blood flow and compared them with those obtained with nocloprost, a potent locally acting gastroprotective agent. Sucralfate and nocloprost given intragastrically (i.g.) protected dose dependently the gastric mucosa against the damage by absolute ethanol and prevented the decrease in blood flow induced by ethanol. Pretreatment with N G -nitro-L-arginine (L-NNA), an inhibitor of NO synthase decreased dose dependently the protection and the maintenance of blood flow provided by sucralfate but not by nocloprost. This decrease of sucralfate protection was antagonized by L-arginine but not D-arginine. Pretreatment with indomethacin also reversed, in part, the protective and hyperemic effects of sucralfate but the combination of both indomethacin and L-NNA completely abolished these effects. We conclude that sucralfate activates both the NO and PG systems that cooperate in the gastroprotective action of this drug and that NO in not involved in the protection induced by a PGE 2 , analog. |
| Databáze: | OpenAIRE |
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