Emotion recognition impairment and apathy after subthalamic nucleus stimulation in Parkinson's disease have separate neural substrates
| Autor: | Julie Anne Peron, Marc Vérin, Paul Sauleau, F. Le Jeune, Sophie Drapier, Dominique Drapier, Emmanuelle Leray, Isabelle Biseul, David Travers, Bruno Millet, Aurélie Bourguignon, Claire Haegelen |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Deep brain stimulation Parkinson's disease Photic Stimulation Cognitive Neuroscience medicine.medical_treatment Apathy Emotions Experimental and Cognitive Psychology Motor Activity Neuropsychological Tests Nucleus Statistics Nonparametric Behavioral Neuroscience Degenerative disease Subthalamic Nucleus medicine Humans Emotion recognition Deep brain stimulation of the subthalamic Aged Emotion Psychiatric Status Rating Scales Facial expression Memory Disorders Depression Parkinson Disease Recognition Psychology Middle Aged medicine.disease Facial Expression Subthalamic nucleus surgical procedures operative Female medicine.symptom Psychology Neuroscience |
| Zdroj: | Neuropsychologia, Vol. 46, No 11 (2008) pp. 2796-2801 |
| ISSN: | 0028-3932 |
| Popis: | Objective: To test the hypothesis that emotion recognition and apathy share the same functional circuit involving the subthalamic nucleus (STN). Methods:Aconsecutive series of 17 patients with advancedParkinson's disease (PD)was assessed3months before (M−3) and 3 months (M+ 3) after STN deep brain stimulation (DBS). Mean (±S.D.) age at surgery was 56.9 (8.7) years. Mean disease duration at surgery was 11.8 (2.6) years. Apathy was measured using the Apathy Evaluation Scale (AES) at bothM−3 and M3. Patientswere also assessed using a computerised paradigm of facial emotion recognition [Ekman, P., & Friesen, W. V. (1976). Pictures of facial affect. Palo Alto: Consulting Psychologist Press] before and after STN DBS. Prior to this, the Benton Facial Recognition Test was used to check that the ability to perceive faces was intact. Results: Apathy had significantly worsened at M3 (42.5±8.9, p = 0.006) after STN-DBS, in relation to the preoperative assessment (37.2±5.5). Therewas also a significant reduction in recognition percentages for facial expressions of fear (43.1%±22.9 vs. 61.6%±21.4, p = 0.022) and sadness (52.7%±19.1 vs. 67.6%±22.8, p = 0.031) after STN DBS. However, the postoperativeworsening of apathy andemotion recognition impairment were not correlated. Conclusions: Our results confirm that the STN is involved in both the apathy and emotion recognition networks. However, the absence of any correlation between apathy and emotion recognition impairmentsuggests that the worsening of apathy following surgery could not be explained by a lack of facial emotion recognition and that its behavioural and cognitive components should therefore also be taken into consideration. |
| Databáze: | OpenAIRE |
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