Evaluation of sympathetic activity by 123I-metaiodobenzylguanidine myocardial scintigraphy in dilated cardiomyopathy patients with sleep breathing disorder
| Autor: | Yoshihiro Yamashiro, Rine Nakanishi, Hajime Nakano, Shohei Yamashina, Aritomo Inoue, Atsushi Namiki, Shunji Fukunaga, Shinichiro Fujimoto, Junichi Yamazaki, Shuji Nanjo |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Sympathetic Nervous System medicine.drug_class Single-photon emission computed tomography Catecholamines Sleep Apnea Syndromes Internal medicine Iodine-123 Natriuretic Peptide Brain medicine Natriuretic peptide Humans Oximetry Aged Ejection fraction medicine.diagnostic_test business.industry Myocardial Perfusion Imaging Dilated cardiomyopathy General Medicine Middle Aged medicine.disease Oxygen Radiography Pulse oximetry 3-Iodobenzylguanidine Catecholamine Cardiology Breathing Female Radiopharmaceuticals Cardiology and Cardiovascular Medicine business Sleep medicine.drug |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society. 73(4) |
| ISSN: | 1346-9843 |
| Popis: | Background: Because increased sympathetic nervous activity (SNA) in patients with dilated cardiomyopathy (DCM) associated with sleep breathing disorder (SBD) is known to deteriorate the prognosis of cardiac failure, 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy was used as the investigative tool in the present study. Methods and Results: The study group comprised 53 patients (47 men, 6 women; mean age 56 ±3 years) with chronic stable DCM. Patients were divided into SBD(+) or SBD(-) group according to 24-h pulse oximetry results. SBD(+) was defined when the 3% oxygen desaturation index was more than 15/h during sleep. In total, 32 patients were SBD(-) and 21 were SBD(+). In both groups, pulse oximetry were performed during sleep and awakening pulse rate, and measurement of the blood levels of catecholamines and B-type natriuretic peptide was performed. MIBG myocardial scintigraphy and echocardiography were performed at the same time. No significant difference was found between the 2 groups in catecholamine levels or left ventricular ejection fraction. However, MIBG had a significantly increased washout rate and a significantly decreased delayed heart to mediastinum ratio in the SBD(+) group compared with the SBD(-) group. Conclusions: SNA is increased in DCM patients when associated with SBD. MIBG myocardial scintigraphy may be a sensitive method of detecting increased SNA. (Circ J 2009; 73: 686 - 690) |
| Databáze: | OpenAIRE |
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