Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery
| Autor: | Sergei I. Tverdokhlebov, Laura Pastorino, Jordan Read, Andrei Udalov, E.V. Shesterikov, Valeriya L. Kudryavtseva, Gleb B. Sukhorukov, Raphael Guillemet, Stefania Boi, David Gould, Jiaxin Zhang |
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| Rok vydání: | 2021 |
| Předmět: |
microprinting
Materials science Drug Compounding Polyesters Dispersity soft lithography Capsules 02 engineering and technology 030226 pharmacology & pharmacy Microprinting Cell Line Mice 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Polylactic acid Animals Humans General Materials Science Particle Size polylactic acid chemistry.chemical_classification polymer capsules drug delivery Anti-Bacterial Agents Doxycycline Equipment Design HeLa Cells Printing Three-Dimensional Polymer 021001 nanoscience & nanotechnology Biodegradable polymer Polyester chemistry Chemical engineering Three-Dimensional Drug delivery Printing Particle size 0210 nano-technology |
| Zdroj: | ACS Applied Materials & Interfaces |
| ISSN: | 1944-8252 1944-8244 |
| Popis: | This work describes the preparation and characterization of printed biodegradable polymer (polylactic acid) capsules made in two different shapes: pyramid and rectangular capsules about 1 and 11 μm in size. Obtained core-shell capsules are described in terms of their morphology, loading efficiency, cargo release profile, cell cytotoxicity, and cell uptake. Both types of capsules showed monodisperse size and shape distribution and were found to provide sufficient stability to encapsulate small water-soluble molecules and to retain them for several days and ability for intracellular delivery. Capsules of 1 μm size can be internalized by HeLa cells without causing any toxicity effect. Printed capsules show unique characteristics compared with other drug delivery systems such as a wide range of possible cargoes, triggered release mechanism, and highly controllable shape and size. |
| Databáze: | OpenAIRE |
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