Lickometry: A novel and sensitive method for assessing functional deficits in rats after stroke
| Autor: | Rebecca C. Trueman, Stephen B. Dunnett, Tracy D. Farr, Dominic M. Dwyer, David J. Harrison, Jewel Ahmed |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
experimental Drinking Focal ischemia Brief Communication Task (project management) 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Focal Ischemia medicine Methods Animals 0501 psychology and cognitive sciences In patient 050102 behavioral science & comparative psychology Middle cerebral artery occlusion Stroke behaviour (rodent) focal ischaemia 05 social sciences Infarction Middle Cerebral Artery medicine.disease stroke Rats Animal models Behavior (rodent) Neurology Neurology (clinical) Sensorimotor Cortex Psychomotor Disorders Cardiology and Cardiovascular Medicine Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism |
| ISSN: | 1559-7016 0271-678X |
| Popis: | The need for sensitive, easy to administer assessments of long-term functional deficits is crucial in pre-clinical stroke research. In the present study, we introduce lickometry (lick microstructure analysis) as a precise method to assess sensorimotor deficits up to 40 days after middle cerebral artery occlusion in rats. Impairments in drinking efficiency compared to controls, and a compensatory increase in the number of drinking clusters were observed. This highlights the utility of this easy to administer task in assessing subtle, long-term deficits, which could be likened to oral deficits in patients. |
| Databáze: | OpenAIRE |
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