Differences in the prevalence of erectile dysfunction between novel subgroups of recent-onset diabetes
| Autor: | Wolfgang Rathmann, Gidon J. Bönhof, Christian Herder, Haifa Maalmi, Michael Roden, Oana-Patricia Zaharia, Klaus Strassburger, Dan Ziegler, Volker Burkart, Julia Szendroedi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Inflammation
medicine.medical_specialty Type 1 diabetes business.industry Endocrinology Diabetes and Metabolism Insulin resistance Type 2 diabetes medicine.disease Article Erectile dysfunction Diabetes subgroups New-onset diabetes Internal medicine Diabetes mellitus Cohort Internal Medicine Medicine Complication business Depression (differential diagnoses) |
| Zdroj: | Diabetologia |
| ISSN: | 1432-0428 0012-186X |
| Popis: | Aims/hypothesis In men with diabetes, the prevalence of erectile dysfunction increases with advanced age and longer diabetes duration and is substantially higher in men with type 2 diabetes than those with type 1 diabetes. This study aimed to evaluate the prevalence of erectile dysfunction among the five novel subgroups of recent-onset diabetes and determine the strength of associations between diabetes subgroups and erectile dysfunction. Methods A total of 351 men with recent-onset diabetes ( Results The prevalence of erectile dysfunction was markedly higher in men with diabetes than in men without diabetes (23% vs 11%, p = 0.004). Among men with diabetes, the prevalence of erectile dysfunction was highest in men with severe insulin-resistant diabetes (SIRD) (52%), lowest in men with severe autoimmune diabetes (SAID) (7%), and intermediate in men with severe insulin-deficient diabetes (SIDD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD) (31%, 18% and 29%, respectively). Men with SIRD had an adjusted RR of 1.93 (95% CI 1.04, 3.58) for prevalent erectile dysfunction (p = 0.038). Similarly, men with SIDD had an adjusted RR of 3.27 (95% CI 1.18, 9.10) (p = 0.023). In contrast, men with SAID and those with MARD had unadjusted RRs of 0.26 (95% CI 0.11, 0.58) (p = 0.001) and 1.52 (95% CI 1.04, 2.22) (p = 0.027), respectively. However, these associations did not remain statistically significant after adjustment. Conclusions/interpretation The high RRs for erectile dysfunction in men with recent-onset SIRD and SIDD point to both insulin resistance and insulin deficiency as major contributing factors to this complication, suggesting different mechanisms underlying erectile dysfunction in these subgroups. Graphical abstract |
| Databáze: | OpenAIRE |
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