Immunoscintigraphy in malignant melanoma
| Autor: | Giancarlo Pansini, Napoleone Prandini, Santini A, Luciano Feggi, Indelli M, Virgili Ar |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Uveal Neoplasms medicine.medical_specialty Skin Neoplasms Scintigraphy Sensitivity and Specificity Immunoscintigraphy medicine Humans Radiology Nuclear Medicine and imaging Melanoma Lymph node Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Technetium General Medicine Middle Aged medicine.disease Optimal management Surgery True negative medicine.anatomical_structure Italy Radioimmunodetection Female Radiology Treatment decision making business Technetium-99m |
| Zdroj: | Nuclear Medicine Communications. 14:145-149 |
| ISSN: | 0143-3636 |
| DOI: | 10.1097/00006231-199302000-00013 |
| Popis: | Immunoscintigraphy (IS) with 99Tcm-labelled anti-melanoma monoclonal antibody F(ab')2 fragments was performed in 135 melanoma patients, 64 males and 71 females, aged 19-82 years (mean 52.3 years) between December 1987 and December 1991. The first group of IS was performed in 50 patients before surgery to assess optimal management: seven true positive and one true negative were obtained in ocular and visceral melanomas, while in cutaneous MM sensitivity, specificity and accuracy in assessing lymph node involvement were, respectively, 61.5, 93.3 and 83.7%. The second group of 128 IS is relative to 85 patients in follow-up: excluding 13 cases with known metastatic disease and 12 inconclusive tests, sensitivity, specificity and accuracy were, respectively, 83.3, 98.8 and 96.1%. Immunoscintigraphy is free of side effects even after repeated administrations and is a useful adjunct to standard diagnostic techniques as a basis for treatment decisions. |
| Databáze: | OpenAIRE |
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