Chlorinated and brominated bisphenol A derivatives: Synthesis, characterization and determination in water samples
| Autor: | Virginie Migeot, Cédric Nadeau, Antoine Dupuis, Philippe Chavatte, Pascal Carato, Pascale Pierre Eugene, Nicolas Venisse, Manon Doumas, Amaury Farce, Steeve Rouillon |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
endocrine system Bisphenol A Environmental Engineering Halogenation Health Toxicology and Mutagenesis chemistry.chemical_element 010501 environmental sciences 01 natural sciences 03 medical and health sciences Human health chemistry.chemical_compound Phenols Chlorine Environmental Chemistry Humans Benzhydryl Compounds 0105 earth and related environmental sciences Chromatography urogenital system Public Health Environmental and Occupational Health Water General Medicine General Chemistry Pollution 030104 developmental biology Endocrine disruptor chemistry Reagent hormones hormone substitutes and hormone antagonists |
| Zdroj: | Chemosphere. 213 |
| ISSN: | 1879-1298 |
| Popis: | Bisphenol A (BPA) has been used in the plastics industry for several decades. During the treatment of drinking water with chlorine reagent, the formation of chlorinated derivatives of BPA (ClxBPA) but also bromoBPA and bromochloroBPA is to be expected. Some of these compounds are considered to have an estrogenic effect and could induce major risks for human health by targeting different organs and systems in the body. In this paper, we describe the synthesis of chloro- and bromobisphenol A (ClxBPA, BrxBPA, BrxClxBPA)and their analytical characterization. These derivatives could be used as analytical standards in LC-MS/MS or evaluated in in vitro biological tests for their potential as endocrine disruptors. In this study, we evaluated the presence of BPA, ClxBPA in a pilot study from water samples. Range values found for BPA, ClxBPA were respectively 2.8–4169.3 ng/L and 0.8–11.3 ng/L. |
| Databáze: | OpenAIRE |
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