TwinsUK: The UK Adult Twin Registry Update
| Autor: | Darioush Yarand, Ruth C. E. Bowyer, Paraskevi Christofidou, Cristina Menni, Jordana T. Bell, Genevieve Lachance, Serena Verdi, Kerrin S. Small, Deborah J. Hart, Massimo Mangino, Claire J. Steves, Golboo Abbasian, Tim D. Spector, Frances M K Williams, Mario Falchi, Christopher J Hammond |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Genetic Markers Male 0301 basic medicine Gerontology medicine.medical_specialty Adolescent Twins Complex disease Young Adult 03 medical and health sciences 0302 clinical medicine Epidemiology Diseases in Twins medicine Humans Longitudinal Studies Registries Healthy aging Genetics (clinical) Exome sequencing Aged Aged 80 and over business.industry Incidence Obstetrics and Gynecology Middle Aged Omics Twin study United Kingdom 030104 developmental biology Genetic epidemiology Pediatrics Perinatology and Child Health Cohort Metabolome Metagenome Female business 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Twin Research and Human Genetics. 22:523-529 |
| ISSN: | 1839-2628 1832-4274 |
| DOI: | 10.1017/thg.2019.65 |
| Popis: | TwinsUK is the largest cohort of community-dwelling adult twins in the UK. The registry comprises over 14,000 volunteer twins (14,838 including mixed, single and triplets); it is predominantly female (82%) and middle-aged (mean age 59). In addition, over 1800 parents and siblings of twins are registered volunteers. During the last 27 years, TwinsUK has collected numerous questionnaire responses, physical/cognitive measures and biological measures on over 8500 subjects. Data were collected alongside four comprehensive phenotyping clinical visits to the Department of Twin Research and Genetic Epidemiology, King’s College London. Such collection methods have resulted in very detailed longitudinal clinical, biochemical, behavioral, dietary and socioeconomic cohort characterization; it provides a multidisciplinary platform for the study of complex disease during the adult life course, including the process of healthy aging. The major strength of TwinsUK is the availability of several ‘omic’ technologies for a range of sample types from participants, which includes genomewide scans of single-nucleotide variants, next-generation sequencing, metabolomic profiles, microbiomics, exome sequencing, epigenetic markers, gene expression arrays, RNA sequencing and telomere length measures. TwinsUK facilitates and actively encourages sharing the ‘TwinsUK’ resource with the scientific community — interested researchers may request data via the TwinsUK website (http://twinsuk.ac.uk/resources-for-researchers/access-our-data/) for their own use or future collaboration with the study team. In addition, further cohort data collection is planned via the Wellcome Open Research gateway (https://wellcomeopenresearch.org/gateways). The current article presents an up-to-date report on the application of technological advances, new study procedures in the cohort and future direction of TwinsUK. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|