Local and Systemic Functional Responses of Mouse Macrophages to Intravaginal Infection with Type 2 Herpes Simplex Virus and Vaccination
| Autor: | L. G. Zaitseva, G. M. Shaposhnikova, I. V. Kireeva, V. A. Bekhalo, V. G. Nesterenko, I. F. Barinskii, E. V. Nagurskaya |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Herpesvirus 2 Human Phagocytosis Cathepsin D Spleen Biology medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Mice 03 medical and health sciences 0302 clinical medicine medicine Extracellular Animals Macrophage Mice Inbred BALB C Macrophages Vaccination General Medicine 030104 developmental biology Herpes simplex virus medicine.anatomical_structure Mice Inbred DBA Vagina Immunology Female 030215 immunology |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 163:68-72 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Activity of cathepsin D and phagocytosis of macrophages from vaginal lavage fluid, peritoneal exudation, and spleen were studied in mice of sensitive (DBA/2) and resistant (BALB/c) lines after intravaginal infection with type 2 herpes simplex virus and vaccination. Activity of cathepsin D and intensity of phagocytosis (irrespective of the macrophage source) and their ratio in BALB/c mice in early terms after infection were close to the control levels taken as a unit. In DBA/2 mice, these parameters and their balance were shifted and changes in cathepsin D activity depended on the time after challenge. Activities of cellular and extracellular cathepsin D increased sharply on day 1 postinfection under conditions of local virus interaction with the vaginal mucosa and activation of the pathological process. Later, after generalization of the infection, activity of cathepsin D decreased, while phagocytosis increased in all the studied macrophage populations. Vaccination corrected the cathepsin D/phagocytosis imbalance and created conditions for rapid elimination of the virus. |
| Databáze: | OpenAIRE |
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