More Protection of Lactobacillus acidophilus Than Bifidobacterium bifidum Probiotics on Azoxymethane-Induced Mouse Colon Cancer
| Autor: | Sahar Bahmani, Peyman Ranji, Ali Mohammad Alizadeh, Hossein Khavari-Daneshvar, Farnaz Ghasemian, Abbas Tavassoli, Shahram Agah, Maryam Mosavi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Colorectal cancer 030106 microbiology ved/biology.organism_classification_rank.species Azoxymethane digestive system Microbiology Gastroenterology law.invention Interferon-gamma Mice 03 medical and health sciences Probiotic chemistry.chemical_compound fluids and secretions Lactobacillus acidophilus law Internal medicine otorhinolaryngologic diseases medicine Animals Humans Molecular Biology Mice Inbred BALB C Bifidobacterium bifidum ved/biology business.industry Probiotics food and beverages Cancer medicine.disease Interleukin-10 030104 developmental biology Mouse Colon chemistry Colonic Neoplasms Molecular Medicine business CD8 |
| Zdroj: | Probiotics and Antimicrobial Proteins. 11:857-864 |
| ISSN: | 1867-1314 1867-1306 |
| DOI: | 10.1007/s12602-018-9425-8 |
| Popis: | Based on the ability of the probiotics in the gut microflora modification, they can have the beneficial effects on diseases in the short and/or the long term. In previous study, we revealed that unlike Bifidobacterium bifidum, the amount of Lactobacillus acidophilus remained almost unchanged in mice gut microflora in the long term, indicating more stability of L. acidophilus than B. bifidum which can be used to prevent some incurable diseases such as cancer. Thirty-eight male BALB/c mice were divided into four groups, control, azoxymethane (AOM), L. acidophilus, and B. bifidum probiotics, to evaluate the protective effects of the probiotics on AOM-induced mouse colon cancer. Except for the control group, the rest of the animals were weekly given AOM (15 mg/kg, s.c) in three consecutive weeks. Colon lesion incidence was 74% in the AOM group in comparison with the control (0%) (P 0.05). The lesions were varied from mild to severe dysplasia and colonic adenocarcinoma. Administration of the probiotics inhibited the incidence of colonic lesions by about 57% in L. acidophilus (P 0.05) and 27% in B. bifidum (P 0.05) compared to the AOM group. The serum levels of CEA and CA19-9 tumor markers were significantly decreased in L. acidophilus in comparison with the AOM group (P 0.05). Moreover, the serum levels of IFN-γ and IL-10 and the number of CD4 |
| Databáze: | OpenAIRE |
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