Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: The dyad hypothesis
| Autor: | Joy A. Umbach, Cameron B. Gundersen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
SNAREs
Statistics and Probability Models Neurological Membrane fusion Biology Exocytosis Mathematical Sciences General Biochemistry Genetics and Molecular Biology Regulatory molecules Synaptotagmins Mice Models Synaptotagmin II Information and Computing Sciences Protein palmitoylation Animals C2 domains Evolutionary Biology General Immunology and Microbiology Applied Mathematics Cell Membrane Neurosciences Lipid bilayer fusion General Medicine Biological Sciences Cysteine string proteins Synaptic vesicle exocytosis Biochemistry Synaptotagmin I Modeling and Simulation Neurological Synaptic Vesicles General Agricultural and Biological Sciences Neuroscience Dyad |
| Zdroj: | Journal of theoretical biology, vol 332 Gundersen, CB; & Umbach, JA. (2013). Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: The dyad hypothesis. Journal of Theoretical Biology, 332, 149-160. doi: 10.1016/j.jtbi.2013.04.029. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5760s9wm |
| ISSN: | 0022-5193 |
| DOI: | 10.1016/j.jtbi.2013.04.029 |
| Popis: | The dyad model was developed to explain the extremely rapid kinetics of synaptic vesicle exocytosis. In contrast to most hypotheses which invoke interactions among synaptotagmins, SNAREs and other regulatory molecules, the dyad model features a quartet of synaptotagmins arrayed at the synaptic vesicle-plasma membrane interface. Ca2+-triggered movements of these synaptotagmins initiate a sequence of events culminating in the fusion of the vesicular and plasma membranes. The relative simplicity of this model and its amenability to empirical testing provide a useful template for future investigations of the molecular events underlying the exocytotic cascade. © 2013 Elsevier Ltd. |
| Databáze: | OpenAIRE |
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