Eating ‘Junk-Food’ Produces Rapid and Long-Lasting Increases in NAc CP-AMPA Receptors: Implications for Enhanced Cue-Induced Motivation and Food Addiction
| Autor: | Luis F. Lopez-Santiago, Max F. Oginsky, Paulette B. Goforth, Carrie R. Ferrario, Cameron W Nobile |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Food addiction media_common.quotation_subject Craving AMPA receptor Nucleus accumbens Nucleus Accumbens Developmental psychology Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Cocaine Dopamine Uptake Inhibitors Internal medicine medicine Animals Obesity Receptors AMPA media_common Pharmacology Motivation Addiction digestive oral and skin physiology Feeding Behavior medicine.disease Rats Behavior Addictive Disease Models Animal Psychiatry and Mental health 030104 developmental biology Endocrinology Gene Expression Regulation Food Schizophrenia Calcium Original Article Psychopharmacology Cues medicine.symptom Psychology Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Neuropsychopharmacology |
| ISSN: | 1740-634X 0893-133X |
| DOI: | 10.1038/npp.2016.111 |
| Popis: | Urges to eat are influenced by stimuli in the environment that are associated with food (food cues). Obese people are more sensitive to food cues, reporting stronger craving and consuming larger portions after food cue exposure. The nucleus accumbens (NAc) mediates cue-triggered motivational responses, and activations in the NAc triggered by food cues are stronger in people who are susceptible to obesity. This has led to the idea that alterations in NAc function similar to those underlying drug addiction may contribute to obesity, particularly in obesity-susceptible individuals. Motivational responses are mediated in part by NAc AMPA receptor (AMPAR) transmission, and recent work shows that cue-triggered motivation is enhanced in obesity-susceptible rats after ‘junk-food' diet consumption. Therefore, here we determined whether NAc AMPAR expression and function is increased by ‘junk-food' diet consumption in obesity-susceptible vs -resistant populations using both outbred and selectively bred models of susceptibility. In addition, cocaine-induced locomotor activity was used as a general ‘read out' of mesolimbic function after ‘junk-food' consumption. We found a sensitized locomotor response to cocaine in rats that gained weight on a ‘junk-food' diet, consistent with greater responsivity of mesolimbic circuits in obesity-susceptible groups. In addition, eating ‘junk-food' increased NAc calcium-permeable-AMPAR (CP-AMPAR) function only in obesity-susceptible rats. This increase occurred rapidly, persisted for weeks after ‘junk-food' consumption ceased, and preceded the development of obesity. These data are considered in light of enhanced cue-triggered motivation and striatal function in obesity-susceptible rats and the role of NAc CP-AMPARs in enhanced motivation and addiction. |
| Databáze: | OpenAIRE |
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