| Autor: |
Hee J. Kim, Ester Del Duca, Ana B. Pavel, Giselle K. Singer, Brian J. Abittan, Margot A. Chima, Grace Kimmel, Jennifer Bares, Danielle Baum, Matthew Gagliotti, Jordan Genece, Justin Chu, Mark G. Lebwohl, Emma Guttman-Yassky |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Archives of Dermatological Research. 315:215-221 |
| ISSN: |
1432-069X |
| Popis: |
Improved repigmentation of generalized vitiligo in skin types IV-VI has been reported in clinical response to combined therapy with apremilast and narrowband (NB)-UVB; however, tissue responses to combined therapy versus NB-UVB monotherapy have not been elucidated. We compared the change from baseline in cellular and molecular markers in vitiligo skin after combined therapy versus NB-UVB monotherapy. We assessed lesional and nonlesional skin samples from enrolled subjects and evaluated for immune infiltrates, inflammatory, and melanogenesis-related markers which were compared across different treatment groups. Combined therapy resulted in significant reduction of CD8 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full text from SpringerLink